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UPNEEQ®

(oxymetazoline hydrochloride ophthalmic solution), 0.1%
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Starting at $5.33/vial

Upneeq® is the only FDA-approved prescription eyedrop for acquired ptosis (low-lying lids) that lifts your upper eyelids to open your eyes.

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1 Box

30 Uses
upneeq where to buy

$190

$160

3 Boxes

90 Uses
Upneeq-3-boxes
$480
$449

3 Boxes

Quarterly Subscription
Upneeq-3-boxes
$480
$349
1 Box
30 Uses
upneeq where to buy
$190
$160
3 Boxes
90 Uses
Upneeq-3-boxes
$480
$449

3 Boxes

Quarterly Subscription

Upneeq-3-boxes
$480
$349
eye-01

5 Min.

In one study, some patients saw a lift in their eyelids as fast as 5 minutes after the first dose.

84%

of patients had some form of improvement.

eye-02
eye-03

74%

of patients had some more than a 50% improvement.

5 Mins.

In one study, some patients saw a lift in their eyelids as fast as 5 minutes after the first dose.

eye-04

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IMPORTANT SAFETY INFORMATION

What is UPNEEQ? UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults.

What warnings and precautions are associated with UPNEEQ?

  • Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.

  • UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.

  • Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.

  • UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.

  • Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used.

What are the most common side effects of UPNEEQ?

The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.

What should my doctor know about before prescribing me UPNEEQ?

  • Your doctor should review your full medical history before prescribing UPNEEQ.

  • UPNEEQ belongs to a class of medication (alpha-adrenergic agonists) that may affect your blood pressure. Use UPNEEQ carefully if you currently take an alpha-adrenergic agonist medication to treat heart disease or an enlarged prostate. Patients taking beta-blockers, or other medications to treat hypertension or an abnormal heartbeat, should also be careful when using UPNEEQ.

  • Patients who use a certain class of antidepressant medication (monoamine oxidase inhibitors) should also be careful when using UPNEEQ, as it may affect the way your body absorbs the medication.

These are not all of the possible side effects of UPNEEQ. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects. To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch. This is a summary of the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ.

Upneeq should only be used as directed

  • Upneeq is designed to only be applied as an eyedrop

  • Each vial contains enough Upneeq solution to allow for one drop in each affected eye

  • The solution should never be swallowed or ingested in any other way

  • Storage requirements: Upneeq should be stored at 68°F-77°F (20°C-25°C) and should be protected from excessive heat

  • Keep out of reach of children

Questions? We're here to help.

UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat low-lying lids (acquired blepharoptosis) in adults.

The most common adverse reactions with UPNEEQ® (occurring in 1-5% of patients) were eye inflammation, eye redness.

In the trial, the onset of the drop was statistically significant at 15 minutes, although many patients responded as early as 5 minutes.

If you wear contact lenses, remove them before instilling Upneeq eye drops. You may put them back in 15 minutes after administering Upneeq.

If more than one medication or eye drop is being used in the eye, they should be administered at least 15 minutes apart.

Step 1: Cut open foil wrapper and remove single-use vial
Step 2: Apply one drop of UPNEEQ® in each affected eye as directed, once a day. Do not let the tip of the vial touch your eye or any other surface. Vials should not be re-usedafter opening and should be thrown away after applying drop(s)

  • If you wear contact lenses, remove them before applying UPNEEQ®eyedrops
  • You may put them back in 15 minutes after applying UPNEEQ®
  • If more than one topical ophthalmic drug is being used, the drugs should be administered at least 15 minutes between applications

Most patients in clinical trials had a lift in their eyelids for 6–8 hours.

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